Annals of Clinical Microbiology and Antimicrobials (2015)
|Publication Type||Journal Article|
The antimicrobial activity of Mul-1867, a novel synthetic compound, was tested against 18 bacterial strains, including clinical isolates and reference strains from culture collections.
The minimal inhibitory concentration (MICs) and minimal bactericidal concentration (MBCs) were determined by using the broth macrodilution method. The kinetics of the inhibitory effects of Mul-1867 against biofilm-growing microorganisms was assessed at time-kill test in vitro against 48-h-old biofilms of Staphylococcus aureus and Escherichia coli. Transmission electron microscopy analyses was conducted to examine cell disruption.
A comparative assessment of the antimicrobial activities of Mul-1867 and chlorhexidine
Overall, these data indicated that Mul-1867 may be a promising antimicrobial for the treatment and prevention of human infections.
|Year of Publication||2015|
|Journal||Annals of Clinical Microbiology and Antimicrobials|